Despite Al Ahly director of football Wael Gomaa stating his desire for Trézéguet to remain with the club, describing him as "one of the main elements of the team", on 6 August 2015, Trézéguet joined Belgian side Anderlecht on loan for a fee of €1 million, with Anderlecht gaining an option to sign him on a permanent basis after the season-long loan for a further €2.5 million.