As of 2024, five prime ministers have served under his presidency, among them Matteo Renzi, then the PD's leader and main sponsor of his presidential candidacy, Paolo Gentiloni, a leading member of the PD who succeeded Renzi after his resignation in 2016, Giuseppe Conte, at that time an independent politician who governed both with right-wing and left-wing coalitions in two consecutive cabinets, Mario Draghi, a banker and former president of the European Central Bank, who was appointed by Mattarella to lead a national unity government following Conte's resignation, and Giorgia Meloni, Italy's first ever female prime minister and leader of the right-wing coalition which won the general election in September 2022.