It was confirmed on May 13, 2007, that Fernando Vargas (26-4-0) would face Mayorga on September 8, 2007, on Showtime PPV for the vacant WBC Continental Americas super middleweight title.
However the fight was postponed after it was discovered during a routine blood test that Vargas was suffering from a severe iron deficiency.
Doctors ordered Vargas not to participate in the upcoming bout until he received the necessary weeks of treatment to correct the problem.
When the bout eventually took place it would be fought at 162 pounds, a weight that neither boxer has ever fought at.
Many sources claim that Vargas had complained about fighting at the Jr. Middleweight limit of 154 pounds, stating that it's "too much for his body to take".
Vargas has stated that fighting at that weight was the reason he did poorly against Mosley in the second fight.
Vargas claimed that this would be the last fight of his career regardless of the result.
He warned Mayorga that he would not tolerate any insults from him like the ones he hurled at De La Hoya in their press conferences.
Vargas stayed true to his promise when at the first official press conference for the fight, Mayorga said some offensive things towards Vargas and attempted to slap him.
Vargas immediately jumped up from his seat and retaliated with punches and a brawl broke out between the two fighters' camps, though order was quickly restored.
Vargas also recalled the time when Mayorga said Vargas was scared of him when he had defeated Javier Castillejo, then was stripped of his WBC light middleweight title rather than face Mayorga, who then defeated Michele Piccirillo for the vacant title.
1931
Cory Spinks (31-2-0) rose to boxing stardom by unifying the WBC, WBA, IBF, and The Ring lineal welterweight titles on December 13, 2003, when he defeated Mayorga by majority decision.
Spinks was a 5 to 1 underdog going into the fight with Mayorga.
The judges scored the fight 114–112, 117–109, 114-114, favoring Spinks.
1935
In January 2003, Vernon Forrest (35-0-0) fought Mayorga.
Mayorga was a mostly unknown fringe contender from Nicaragua and few gave him a chance to win against the significantly bigger and stronger Forrest.
Mayorga shocked the world when he easily dominated Forrest, dropping him once in the 1st round and again in the 3rd round.
The referee would call off the fight after the second knockdown, as Forrest was visibly dazed and unable to get his footing.
Forrest would rematch Mayorga six months later, losing again, this time by a majority decision.
The bout was close and competitive, with Mayorga mostly chasing Forrest around the ring while Forrest was content to fight from the outside.
1941
Félix Trinidad (41-1-0) announced a comeback on March 2, 2004.
1973
Ricardo Antonio Mayorga Perez (born October 3, 1973) is a Nicaraguan professional boxer and former mixed martial artist.
2002
Lewis's lost the title in a rematch to Mayorga in 2002 via 5th-round TKO.
2003
In boxing he is a former two-weight world champion, having held the unified WBA (Unified), WBC, Ring magazine, and lineal welterweight titles in 2003, and the WBC super welterweight title from 2005 to 2006.
Mayorga first became well known to boxing fans upon being featured on the cover of The Ring's December 2003 issue, entitled "The craziest man in the sport: Mayorga lights up boxing." He has since maintained this infamous reputation with his relentless trash-talk in the build-up to most of his fights, as well as his smoking and drinking habits outside the ring.
After defending the title against Larry Marks, Andrew Lewis took on Mayorga.
The bout ended in the 2nd round and was ruled a No Contest due to a nasty cut on Lewis caused by accidental headbutt.
2004
On October 2, 2004, he fought against Mayorga, in Madison Square Garden.
Early in the 1st round Mayorga was on the offensive connecting several combinations, later in the round Trinidad connected some punches to his opponent's face.
Mayorga reacted defiantly while lowering his defense, which Trinidad used to continue the offensive during the closing seconds.
In the 2nd round, Trinidad continued connecting with combinations to Mayorga's face which caused him to bleed from his nose; the round concluded with both fighters exchanging punches.
In the 3rd round, Mayorga attempted to counter with punches to the body but did not do significant damage to his opponent, however later in the round one of these punches made Trinidad lose his balance and touch the floor with one glove which the referee counted as a knockdown.
In the 4th round, both boxers traded hard combinations.
In the 5th round, Trinidad displayed control of the offense's tempo injuring Mayorga and opening a cut under one of his eyes.
This pattern continued in the 6th and 7th round, and the cut on Mayorga's face began to swell.
In the 8th round, Trinidad scored several knockdowns, Mayorga continued after two knockdowns, but lost by technical knockout following a third knockdown.
Oscar De La Hoya (37–4-0) took a layoff of 20 months before signing to fight Mayorga.
2006
In the buildup to the fight, Mayorga insulted everything from De La Hoya's sexuality to his wife and child, but when they fought on May 6, 2006, De La Hoya knocked Mayorga down in the first minute of the fight with a left hook.
De La Hoya knocked him out in the 6th round to take his tenth world title.
2007
Ultimately the contestants faced off, and Mayorga defeated Vargas by majority decision on November 23, 2007.
