Apart from serving as the Additional Principal Secretary in the Prime Minister's Office, Mishra has served in various key positions for both Indian and Gujarat governments, such as the Additional Chief Secretary (Revenue), Principal Secretary (Agriculture and Cooperation), Principal Secretary to the Chief Minister of Gujarat, member of the Gujarat Electricity Board, and as the district magistrate and collector of Mehsana and Banaskantha districts in the Government of Gujarat, and as the Union Agriculture Secretary, special secretary in Ministry of Home Affairs, additional secretary in Ministry of Urban Development, and as the member secretary of National Capital Region Planning Board in the Government of India.