His second novel, Les Particules Élémentaires (translated by Frank Wynne and published in the English-speaking world as Atomised in the UK, or The Elementary Particles in the US) was a breakthrough, bringing him national and soon international fame and controversy for its intricate mix of brutally honest social commentary and pornographic depictions (two years earlier, in 1996, while working on that novel, being interviewed by Andrew Hussey, he had presciently said : "It will either destroy me or make me famous." ) It narrates the fate of two half brothers who grew up in the troubled 1960s: Michel Djerzinski, who became a prominent biologist, highly successful as a scientist but utterly withdrawn and depressed, and Bruno Clément, a French teacher, deeply disturbed and obsessed by sex; Djerzinski eventually triggers what is labelled as the "third metaphysical mutation" by retro-engineering the human species into immortal neo-humans.