He then beat Gaël Monfils in a fifth set tiebreak to become the first Italian man to reach the US Open semifinals since 1977.
Berrettini's run ended against eventual champion Rafael Nadal in straight sets, despite holding two set points in the opening-set tiebreak.
Pursuing an ATP Finals berth, Berrettini achieved his best Masters result yet at the Shanghai Masters by reaching the semifinals.
Along the way Berrettini claimed his second career top-5 victory by beating Dominic Thiem in the quarterfinals.
Another semifinal appearance at the Vienna Open saw Berrettini break into the top ten rankings.
1990
He also became the first man born in the 1990s and first Italian man to reach the quarterfinals or better at all four majors after earning his first Australian Open semifinal in 2022.
1996
Matteo Berrettini ( born 12 April 1996) is an Italian professional tennis player.
He has been ranked as high as world No. 6 in singles by the Association of Tennis Professionals (ATP), which he achieved in January 2022, and world No. 105 in doubles, attained in July 2019.
Berrettini has won seven ATP Tour singles titles and two doubles titles, and produced his best major performance by reaching the singles final of the 2021 Wimbledon Championships.
1999
Berrettini's serve was not broken throughout the entire tournament, thereby making him only the fifth man since 1999 to win two tournaments without dropping serve (the other occasion coming at the 2018 Gstaad Open).
The following week, Berrettini reached his first ATP 500 semifinal at the Halle Open where he was defeated by David Goffin.
Following the tournament, the Italian broke into the top-20.
2015
After turning professional in 2015, Berrettini won two singles titles on the ITF World Tennis Tour and three on the ATP Challenger Tour, breaking into the top 100 of the ATP rankings in May 2018.
2017
As the 17th seed at Wimbledon, Berrettini reached the fourth round of a Grand Slam for the first time after defeating Diego Schwartzman in five sets.
He then lost to eight-time champion Roger Federer comprehensively in 74 minutes.
After congratulating Federer for his win during their post-match handshake, Berrettini jokingly asked Federer, "Thanks for the tennis lesson, how much do I owe you?"
Berrettini withdrew from his next two events in Gstaad and Montreal, citing an ankle injury.
He played a lead-up tournament in Cincinnati before competing in the US Open.
There, despite his lack of preparation, Berettini reached his first Major quarterfinal after defeating Andrey Rublev in the fourth round.
2018
Two months later, he reached his first ATP Tour final at the 2018 Swiss Open, where he won his maiden title and made his top 60 debut.
After qualifying for the 2018 Qatar ExxonMobil Open, ranked No. 135, he notched his first tour-level win over No. 55 Viktor Troicki.
On his next tournament, he entered his first Grand Slam main draw as a lucky loser at Australian Open but lost in the first round to No. 27 Adrian Mannarino.
He entered the 2018 BNP Paribas Open as a lucky loser replacing 17th seed Nick Kyrgios directly in the second round.
At the Swiss Open Gstaad, Berrettini won his first ATP title, defeating Roberto Bautista Agut in the final.
He also won his first ATP doubles title at the same event, partnering with Daniele Bracciali.
At the Hungarian Open, Berrettini won his second ATP singles title, defeating Filip Krajinović in the final.
Berrettini continued his form into the following week as he reached the final at the Bavarian International Tennis Championships.
There, his nine-match winning streak was snapped by Cristian Garín in a third set tie-breaker.
At the Italian Open, Berrettini upset Alexander Zverev in the round of 32 for his first win against a top-5 player.
Berrettini's improvement continued into the grass court season, winning his third singles title in Stuttgart over Félix Auger-Aliassime in the final.
2019
In 2019, after claiming two further titles at the Hungarian Open and Stuttgart Open, he entered into the top 25, and carried his momentum into his maiden career major semifinal at the US Open to end the year ranked in the top 10.
Berrettini made additional strides in 2021 after reaching his first Masters 1000 final at the Madrid Open, winning his first ATP 500 title at the Queen's Club Championships, and becoming the first Italian player, male or female, to contest a Wimbledon singles final.
Berrettini is known for his aggressive game style boosted by his large build.
At 1.96m, Berrettini possesses one of the tour's fastest serves and often uses his heavy topspin forehand to dictate rallies and set up one-two punches, making him versatile on all surfaces.
In order to compensate for his weaknesses, he often deploys his backhand slice to keep the ball low for his opponent and uses a blocked return to neutralize points.
As an all-court player, he has also developed these tactics to be comfortable at the net to close points.
Berrettini made his ATP main draw debut at the Italian Open after earning a wildcard in the pre-qualifying wildcard tournament.
He was defeated by Fabio Fognini in the first round.
He was the top seed in the eight man Italian field competing for the final spot in the inaugural Next Generation ATP Finals in Milan, but lost to Filippo Baldi in straight sets.
As world number 8, Berrettini claimed the final spot in the 2019 ATP Finals in London.