Louise Brown

Her younger sister, Natalie Brown, was also conceived through IVF four years later, and became the world's 40th child born after conception by IVF.

On 10 November 1977, Lesley Brown underwent a procedure, later to become known as in vitro fertilisation (IVF), developed by Patrick Steptoe, Robert Edwards, and Jean Purdy.

Purdy was the first to see her embryonic cells dividing.

Louise Joy Brown (born 25 July 1978) is an English woman who was the first human to have been born after conception by in vitro fertilisation experiment (IVF).

Her birth, following a procedure pioneered in Britain, has been lauded among "the most remarkable medical breakthroughs of the 20th Century".

Louise Joy Brown was born at Oldham General Hospital, Lancashire, by planned Caesarean section performed by registrar John Webster.

She weighed 5 pounds, 12 ounces (2.608 kg) at birth.

Her parents, Lesley and John Brown, had been trying to conceive naturally for nine years, but Lesley faced complications of blocked fallopian tubes.

In 1978, when asked for his reaction to Brown's birth, the patriarch of Venice, Cardinal Albino Luciani (later Pope John Paul I), expressed concerns about the possibility that artificial insemination could lead to women being used as "baby factories", but also refused to condemn the parents of the child, noting they simply wanted to have a baby.

In May 1999, Natalie was the first human born after conception by IVF to give birth herself—without IVF.

In 2004, Brown married nightclub doorman Wesley Mullinder.

Dr. Edwards attended their wedding.

Their first son, conceived naturally, was born on 20 December 2006.

Brown's father died in 2006.

Edwards, as the only surviving partner, was awarded the 2010 Nobel Prize in Medicine for this work.

In March 2022, a plaque was installed on Royal Oldham Hospital to record the importance of Sister Muriel Harris and Jean Purdy to the work.

Although the media referred to Brown as a "test tube baby", her conception actually took place in a Petri dish.

Her mother died on 6 June 2012 in Bristol Royal Infirmary at the age of 64 due to complications from a gallbladder infection.

Although the Browns knew the procedure was experimental, the doctors did not tell them that no case had yet resulted in a baby.

This has raised questions of informed consent.