He married his second cousin once removed, Grand Duchess Kira Kirillovna of Russia, in 1938 in first a Russian Orthodox ceremony in Potsdam and then a Lutheran ceremony in Huis Doorn, Netherlands. Kira was the second daughter of Grand Duke Kyril Vladimirovich and Princess Victoria Melita of Saxe-Coburg and Gotha. The couple had four sons and three daughters. His two eldest sons both renounced their succession rights in order to marry commoners. His third son and heir apparent, Prince Louis Ferdinand, died in 1977 during military maneuvers, and thus his one-year-old grandson Georg Friedrich, Prince of Prussia (son of Prince Louis Ferdinand) became the new heir apparent to the defunct Prussian and German Imperial throne. Upon Louis Ferdinand's death in 1994, Georg Friedrich became the pretender to the defunct thrones and head of the Hohenzollern family. After the reunification of Germany, Louis Ferdinand arranged to have the remains of several Hohenzollern members reinterred at the imperial vault in Potsdam.