Bowles was born in Washington, D.C., to Judith (née LeFever) and L. Thompson Bowles.
Her half-sister (on her mother's side) is actress Julia Louis-Dreyfus.
She majored in drama at New York University.
Bowles has appeared in numerous TV shows, including Arrested Development, CSI: Crime Scene Investigation, Judging Amy and Private Practice.
She has appeared with Louis-Dreyfus in programs such as Seinfeld, as a waitress at the diner; The New Adventures of Old Christine, Watching Ellie, and Veep.
She has also appeared in some feature films.
2004
In 2004 Bowles married actor Patrick Fischler, whom she met in college.
2009
Their daughter, Fia Lucille Fischler, was born in April 2009.
2010
In April 2010, she was cast as Holly Cleary, a Wiccan, in the vampire television series True Blood.
She currently appears on XM radio's Take Five channel, where she does features for their Five Minute Magazine.