Pickett was selected by the Pittsburgh Steelers in the first round (20th overall) of the 2022 NFL Draft, the latest a quarterback was first taken in a draft since 1997, and the highest the Steelers selected a quarterback since drafting the then-recently retired Ben Roethlisberger in 2004; the selection was announced by Steelers legend Franco Harris in one of his last public appearances with the team before his unexpected death on December 20, 2022.