At the time of his selection, the Hurricanes’ director of amateur scouting stated ”There’s nobody in the draft that scores goals like Jeff Skinner." During his first NHL training camp, he signed a three-year, entry-level contract with the Hurricanes on September 21, 2010, worth $2.7 million. On October 7, Skinner made his NHL debut with the opening roster in the Hurricanes' 4–3 win against the Minnesota Wild during the NHL Premiere Series in Helsinki, Finland. In 16 minutes of ice time, he had two shots. The following day, Skinner recorded his first career NHL point with an assist on Tuomo Ruutu's goal. He also scored the game winning shootout goal to become the third-youngest player in NHL history to score a shootout goal. On October 20, Skinner scored his first NHL career goal against Jonathan Bernier of the Los Angeles Kings in his fifth game of the season.