During a Twitter exchange in which Manford defended strike action undertaken by British Railway workers in the ASLEF trade union, Manford recalled the various workplaces he had worked in before his current career including building sites, call centres, shops, bars, warehouses and offices, stating "I didn't just leave school and say 'right, I'm off to play the arena!. While working as a glass collector at a local pub, Manford became interested in comedy after watching the likes of Eddie Izzard, Peter Kay and Johnny Vegas perform at the local comedy club. Kay recommended him to undertake an HND in media and performance at the University of Salford, which Kay himself had done. Despite not having the required A-level grades, he was accepted into the programme and eventually upgraded to a full degree. His brother Colin, also a University of Salford graduate, followed him into performing and is also a stand-up comedian.