The film was a box office success in Germany, grossing US$10.5 million domestically, and Variety, in its review for the film, remarked: "Boasting a gutsy performance from sturdy young German star Franka Potente (Run Lola Run), Anatomy is creepy, sometimes gruesome, widescreen fun that pushes all the right buttons. Out-performing Scream at the local [box office] and the biggest German pic of the year so far, this is natural latenight/fantasy fest fare that could become a cult item on half-inch and possibly even theatrically".