He was drafted after the 49ers traded linebacker Dekoda Watson to acquire the 148th pick.
Greenlaw made his NFL debut in the season-opening 31–17 road victory over the Tampa Bay Buccaneers, recording four tackles.
During a Week 9 28–25 road victory over the Arizona Cardinals, he recorded four tackles and his first NFL sack on Kyler Murray.
In the next game against the Seattle Seahawks on Monday Night Football, Greenlaw recorded eight tackles, a pass deflection, and his first NFL interception off of Russell Wilson in a 27–24 overtime loss.
The following week against the Cardinals, Greenlaw recorded 10 tackles as the 49ers won by a score of 36–26.
During a narrow Week 14 48–46 road victory over the New Orleans Saints, Greenlaw recorded seven tackles and a pass deflection.
Two weeks later Los Angeles Rams, he recorded a team-high 13 tackles as the 49ers narrowly won by a score of 34–31.
1997
Ke'Aundre J'Quan "Dre" Greenlaw (born May 25, 1997) is an American football linebacker for the San Francisco 49ers of the National Football League (NFL).
2011
Greenlaw attended Fayetteville Public Schools, playing for a Fayetteville High School football team that won the Class 7A 2011 state championship.
2012
He was named to the Arkansas Democrat-Gazette preseason "Super Sophomore" team in 2012.
Greenlaw started at cornerback, recording 53 total tackles, two forced fumbles, five pass breakups, and an interception on a team that repeated as 7A state champions.
As a junior, he moved to strong safety.
He was considered a three-star recruit by Rivals.com.
Greenlaw played college football under head coaches Bret Bielema and Chad Morris at Arkansas.
2015
He recorded 321 total tackles, four sacks, three interceptions, and four forced fumbles from 2015 to 2018.
2019
He played college football at Arkansas and was drafted by the 49ers in the fifth round of the 2019 NFL Draft.
Greenlaw grew up in group homes and shelters in Arkansas from the age of 8.
At 14 he met Brian Early, defensive coach for Fayetteville High School.
The Early family invited Greenlaw to live with them and formally adopted him at age 21.
Greenlaw was drafted by the San Francisco 49ers in the fifth round (148th overall) of the 2019 NFL Draft.
In the regular-season finale against the Seahawks on Sunday Night Football, Greenlaw once again recorded a team-high 13 tackles and made a critical stop on tight end Jacob Hollister inside of the one-yard line on the final play of the drive, sealing a 26–21 road victory and securing the first seed for the 49ers in the 2019 playoffs.
Greenlaw credited review from the 49ers' Week 15 29–22 loss to the Atlanta Falcons, which ended in a similar scenario where wide receiver Julio Jones was barely able to break the plane into the endzone, for giving him the correct technique to hit Hollister high.
Greenlaw finished his rookie year with 92 tackles, two pass deflections, a sack, and an interception in 16 games and 11 starts.
He was named to the PFWA NFL All-Rookie Team.
The 49ers finished atop the NFC West with a 13–3 record and the #1-seed in the playoffs.
In the Divisional Round against the Minnesota Vikings, Greenlaw recorded four tackles and a forced fumble during the 27–10 win.
During the National Football Conference (NFC) Championship Game against the Green Bay Packers, he recorded six tackles as the 49ers won by a score of 37–20.
During Super Bowl LIV against the Kansas City Chiefs, Greenlaw recorded four tackles as the 49ers lost by a score of 31–20.
During the season-opening 24–20 loss to the Cardinals, Greenlaw recorded five tackles and a pass deflection.
During a Week 6 24–16 victory over the Rams, he recorded a team-high eight tackles.
In the next game against the New England Patriots, Greenlaw recorded six tackles and his first sack of the season on Cam Newton as the 49ers won on the road by a score of 33–6.
During a Week 10 27–13 road loss to the Saints, Greenlaw recorded a team-high 11 tackles.
Greenlaw finished his second professional season with 86 tackles, a pass deflection, and a sack in 13 games and 11 starts.
During the season-opening 41–33 road victory over the Detroit Lions, Greenlaw recorded six tackles and his first defensive touchdown on a pick six off of Jared Goff.
Greenlaw was placed on injured reserve on September 18, 2021, after undergoing groin surgery.
He was activated on November 27.
In the regular-season finale against the Rams, Greenlaw recorded a team-high 12 tackles in the 27–24 overtime road victory.
Greenlaw finished the 2021 season with 21 tackles, a pass deflection, and a pick-six in three games and two starts.
The 49ers finished the season with a 10–7 record and earned the #7 seed in the playoffs.
In the Wild Card Round against the Dallas Cowboys, Greenlaw recorded five tackles in the 23–17 road victory.