The highlight of Myskina's 2004 season was a victory at the French Open, where she saved match points in the fourth round against Svetlana Kuznetsova, then defeated former world No. 1 players Venus Williams and Jennifer Capriati, en route to a 6–1, 6–2 victory over compatriot Elena Dementieva in the first all-Russian Grand Slam final, thus making her the first female Russian to win a Grand Slam singles title.