Busia's film roles include a notable performance as Bessie in a 1986 film adaptation of Richard Wright's novel Native Son (with Geraldine Page and Matt Dillon. She also starred in Hard Lessons alongside Denzel Washington and Lynn Whitfield in 1986. Busia played Nettie (opposite Danny Glover and Whoopi Goldberg) in Steven Spielberg's 1985 The Color Purple, adapted from Alice Walker's novel of the same title, as Ruth in Badge of the Assassin (1985), as Jewel in John Singleton's Rosewood (1997), and as Patience in Antoine Fuqua's Tears of the Sun (2003). She has also appeared on television in the series ER.